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Bakthadoss Research Group

Department of Chemistry

Pondicherry University

Mono and di ortho-C–H acetoxylation of 2-aryloxyquinoline-3-carbaldehydes

Manickam Bakthadoss*a, Oluwafemi S. Ainaab, Tadiparthi Thirupathi Reddya, Josephat U. Izunobib and Oluwole B. Familoni

RSC Adv., 2024, 14, 13306-13310

Palladium-Catalyzed Remote meta-C-H Olefination of Cinnamates

Manickam Bakthadoss*, Mir Ashiq Hussain, Tadiparthi Thirupathi Reddy

Chem. Commun., 2023, 59, 5249–5252

Distal meta-C−H functionalization of α-substituted cinnamates

Manickam Bakthadoss*, Tadiparthi Thirupathi Reddy

Chem. Sci. 2023 , 14, 5880–5886

(Chemical Science Journal Cover page)

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Ester directed orthogonal dual C-H activation and ortho aryl C-H alkenylation via distal weak coordination

Manickam Bakthadoss*, Tadiparthi Thirupathi Reddy, Vishal Agarwal, and Duddu S. Sharada*

Chem. Commun., 2022, 58, 1406 - 1409

Azomethine Ylide Cycloaddition of 1,3- dienyl esters: Highly regio- and diastereoselective synthesis of functionalized pyrrolidinochromenes

Manickam Bakthadoss,* Mohammad Mushaf, Vishal Agarwal, Tadiparthi Thirupathi Reddy and Duddu S. Sharada*

Org. Biomol. Chem., 2022., 20, 778 - 782

Domino ring opening and Selective O/S-alkylation of cyclic ethers and thioethers

Manickam Bakthadoss, Vishal Agarwal, Tadiparthi Thirupathi Reddy, and Mohammad Mushaf

Mol Divers 2021, DOI: 10.1007/s11030-020-10105-2 (In Press)

Construction of hybrid polycyclic quinolinobenzo[a]phenazinone architectures using solid-state melt reaction (SSMR)

Manickam Bakthadoss, and Varathan Vinayagam

Mol Divers 2021, https://doi.org/10.1007/s11030-020-10090-6

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Photocatalytic Visible-Light-Induced Nitrogen Insertion via Dual C(sp3 )−H and C(sp2 )−H Bond Functionalization: Access to Privileged Imidazole-based Scaffolds

Srilaxmi M. Patel, Ermiya Prasad P., Manickam Bakthadoss* Duddu S. Sharada*

Org. Lett. 2020, 23, 257–261

Rhodium-Catalyzed Diastereoselective [3 + 2] Cycloaddition of Carbonyl Ylide: An Access to the Core Ring System of Cordigol and Lophirone H

Manickam Bakthadoss, Vishal Agarwal

J. Org. Chem. 2020, 85, 15221−15231.

Intramolecular [3 + 2] nitrone cycloaddition reaction: highly regio and diastereoselective synthesis of bicyclo[3.2.1]octane scaffolds

Manickam Bakthadoss, Mohammad Mushaf

Org. Biomol. Chem., 2020, 18, 9653-9659

Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone

Manickam Bakthadoss, Tadiparthi Thirupathi Reddy, and Duddu S. Sharada

RSC Adv., 2020, 10, 31570-31574

Cascade Annulation Reaction (CAR): Highly Diastereoselective synthesis of the Pyranopyrazole Scaffolds

Manickam Bakthadoss, and Manickam Surender

RSC Advance 2020, 10, 1903-1907

Assembly of Highly Functionalized Chromenopyranpyrazoles via Multicomponent Quadruple Domino Reaction (MCQDR)

Manickam Bakthadoss, Devaraj Anthonisamy, and Mohammad Mushaf

ChemistrySelect, 2019, 4, 11822– 11825

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Three-Component, One-Pot Sequential Synthesis of Functionalized Hybrid polyheterocyclic Scaffolds via Solid State Melt Reaction.

Bakthadoss, M., Jayakumar Srinivasan, Mir Ashiq Hussain and Duddu S. Sharada.

RSC Adv., 2019,9, 24314-24318

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Three Component, One-Pot Synthesis of Multifunctional Quinolinopyranpyrazoles via Catalyst-Free Multicomponent Reaction

Bakthadoss, M., Varathan Vinayagam, Vishal Agarwal and Duddu S. Sharada

ChemistrySelect 2019, 4, 7996 – 7999

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Ruthenium mediated chemo and site-selective C–H amidation of oxobenzoxazine derivatives with sulfonyl azides

Bakthadoss, M., Polu Vijay Kumar, Ravan Kumar, Manickam Surendar, and Duddu S. Sharada

New J. Chem., 2019, 43, 14190-14195

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Palladium catalysed chemo- and regioselective ortho-C-H acetoxylation and hydroxylation of oxobenzoxazine derivatives

Bakthadoss, M., Polu Vijay Kumar, Ravan Kumar and Vishal Agarwal

Org. Biomol. Chem., 2019, 17, 4465-4469

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A new rearrangement involving solid-state melt reaction (SSMR) for the synthesis of multifunctional tetra substituted olefins

Bakthadoss, M., Raman Selvakumar and Mohammad Mushaf

Org. Biomol. Chem., 2019, 17, 4767-4773

Regioselective C3-H trifluoromethylation of 2H-indazole under transition-metal-free photoredox catalysis

Arumugavel Murugan, Venkata Nagarjuna Babu, Ashok Polu, Nagaraj Sabarinathan, Bakthadoss, M. and Duddu S. Sharada

J. Org. Chem., 2019, 84, 12, 7796-7803

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A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

Bakthadoss, M., Jayakumar, S., Raman, S., Devaraj, A., Sharada, D. S.,

Org. Biomol. Chem., 2019, 17, 3884-3893

(OBC Journal Cover page)

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Triple domino reaction for the synthesis of pyrazole/indoline linked chromenes

Bakthadoss, M., Meegada, S. K.; Surendar, M.

Tetrahedron, 2018, 74, 490-496

Solvent and catalyst free ring expansion of indoles: a simple synthesis of highly functionalized benzazepines

Bakthadoss, M., Kumar P. V., Reddy T. T., Sharada, D. S.,

Org. Biomol. Chem., 2018, 16, 8160-8168

A distal vinyl shift (DVS) through quadruple domino reaction: synthesis of N-vinyl benzoheterocyclic scaffolds

Bakthadoss, M., Mohammad Mushaf

RSC Adv., 2018, 8, 12152-12156

Synthesis of Highly Functionalized Tricyclic Chromenopyrazole Frameworks via Intramolecular Azomethine Imine 1,3‐Dipolar Cycloaddition (IAIDC)

Bakthadoss, M., Vishal Agarwal

ChemistrySelect, 2018, 3(24), 6960-6964

Ruthenium‐Catalyzed Site‐selective Enone Carbonyl Directed ortho‐C−H Activation of Aromatics and Heteroaromatics with Alkenes

Bakthadoss, M., Kumar P. V.,

Adv. Synth. Catal. 2018, 360(14), 2650-2658

A direct cycloaminative approach to imidazole derivatives via dual C-H functionalization

Arepally, S.; Babu, V. N.; Bakthadoss M.; Sharada D. S.

Org. Lett., 2017, 19, 5014–5017

Ruthenium-Catalyzed, Keto-Directed, Site-Selective C–H Activation of Diverse Chromanones with Alkenes

Bakthadoss, M.; Kumar, P. V.; Reddy, T. S.

Eur. J. Org. Chem., 2017, 30, 4439-4444

This article appears in Emerging Investigators from India

Synthesis of a novel methyl (2E)-2-{[N-(2-formylphenyl) (4-methylbenzene) sulfonamido] methyl}-3-(2-methoxyphenyl) prop-2-enoate: Molecular structure, spectral, antimicrobial, molecular docking and DFT computational approaches

Murugavel, S., Vetri velan V., Kannan, D., Bakthadoss, M.

Journal of Molecular Structure, 2017, 1127 457-475

One-Pot Synthesis of Benzothiazole-Tethered Chromanones/Coumarins via Claisen Rearrangement Using the Solid State Melt Reaction

Bakthadoss, M.; Selvakumar, R.

J. Org. Chem. 2016, 81, 3391–3399

Experimental and computational approaches of a novel methyl (2E)-2-[N-(2 formylphenyl)(4-methylbenzene) sulfonamido]methyl-3-(4-chlorophenyl)prop-2enoate: A potential antimicrobial agent and an inhibition of penicillin-binding protein

Murugavel, S., Vetri Velan, V., Kannan, D., Bakthadoss, M.

Journal of Molecular Structure, 2016, 1115, 33-54

Synthesis, crystal structure analysis, spectral investigations, DFT computations, Biological activities and molecular docking of methyl (2E)-2-[N-(2-formylphenyl)(4-methylbenzene) sulfonamido] methyl-3-(4-fluorophenyl)prop-2-enoate, a potential bioactive agent

Murugavel, S., Vetri Velan, V.,Kannan, D., Bakthadoss, M.

Journal of Molecular Structure, 2016, 1108, 150-167

Synthesis of highly diversified 1, 2, 3-triazole derivatives via domino [3 + 2] azide cycloaddition and denitration reaction sequence

Bakthadoss, M.; Sivakumar, N.; Devaraj, A.; Vijay Kumar, P.

RSC Adv., 2015, 5, 93447-93451

Stereoselective construction of functionalized tetra and pentacyclic coumarinopyran pyrazole / pyrimidinedione / coumarin scaffolds using solid state melt reaction

Bakthadoss, M.; Kannan, D.; Sivakumar, N.; Malathi, P.; Manikandan. V.
Org. Biomol. Chem., 2015, 13, 5597-5601

Highly regio- and stereoselective synthesis of novel tri and tetracyclic quinoline architectures throughan intramolecular

[3 + 2] cycloaddition reaction

Bakthadoss, M.; Kannan, D.; Srinivasan. J. Vinayagam, V.
Org. Biomol. Chem. 2015, 13, 2870-2874

Synthesis of benzoxepinopyrrolidines/spiropyrrolidines via oxa-Pictet–Spengler and [3+2] cycloaddition reactions

Bakthadoss. M.; Sivakumar, N.; Devaraj. A

Tetrahedron Lett. 2015, 4980–4983

Synthesis of functionalized cyclohexenols via a domino Michael addition-Dieckmann cyclization-isomerization reaction sequence

Bakthadoss, M., Murugan, G.; Srinivasan, J

Tetrahedron Lett. 2015, 56, 3877–3881

Diastereoselective construction of highly functionalized tetrahydroquinolinoisoxazole scaffolds via intramolecular nitrone cycloaddition

Bakthadoss. M.; Devaraj. A.

Tetrahedron Lett. 2015, 56, 3954–3960

First Synthesis of Bis(di(indolyl)aryl)methanes from Bis salicylaldehydes

Bakthadoss, M.; Devaraj, A.; Srinivasan, J.,
J. Heterocycl. Chem. 2015, 52, 418-424

A facile synthesis of isoxazolo[3,4-a]pyrrolizine and isoxazolo[4,3-c]pyridine derivatives via intramolecular nitrone cycloaddition reaction

Bakthadoss, M., Srinivasan, J.

RSC Adv, 2015, 5, 67206-67209

A novel protocol for the facile construction of tetrahydro quinoline tethered tricyclic frame works via an intramolecular 1, 3 - dipolar nitrile oxide cycloaddition reaction

Bakthadoss, M.; Vinayagam, V.

Org. Biomol. Chem, 2015, 13, 10007-10014

An efficient protocol for the synthesis of biologically active benzoheterocyclic compounds via solid-state melt reaction (SSMR)

Bakthadoss, M.; Selvakumar, R.; Srinivasan. J.

Tetrahedron Lett. 2014, 55, 5808-5812

A novel synthesis of tetra and pentacyclic quinolinopyran tethered pyrazole / coumarin scaffolds via solid state melt reaction

Bakthadoss, M.; Kannan, D.

RCS Adv. 2014, 4, 11723-11731

Highly stereo and chemoselective synthesis of tetra and pentacyclic frameworks using Solid State Melt Reaction (SSMR)

Bakthadoss, M.; Sivakumar, G.

Tetrahedron Lett. 2014, 15, 1765-1770

A simple and direct synthesis of 3-methylene-1,4-diarylazetidin-2-ones and (E)-3-arylidene-1-phenylazetidin-2-ones using Baylis–Hillman derivatives

Bakthadoss, M.; Srinivasan, J.; Selvakumar, R.

Aust. J. Chem. 2014, 67, 295-301

Multicomponent cascade assembly for quinolinopyranpyrazole architectures

Bakthadoss, M.; Devaraj, A.; Kannan, D.

Eur. J. Org. Chem. 2014, 1505-1513

A multicomponent cascade reaction for the synthesis of novel chromenopyranpyrazole scaffolds

Bakthadoss, M.; Kannan, D.; Selvakumar. R.

Chem. Commun. 2013, 49, 10947-10949

Highly regio- and stereoselective synthesis of tetracyclic indolenoisoxazolidines via intramolecular 1,3-dipolar nitrone cycloadditions

Bakthadoss, M.; Sivakumar, G.; Sharada, D. S.
Synthesis, 2013, 237-245

Synthesis of novel vicinal coumarin- and oxindole-functionalized dispiropyrrolidines and dispiropyrrolizidines via [3+2]-cycloaddition reactions

Bakthadoss, M; Kannan, D; Sivakumar, G.
Synthesis, 2012, 44, 793-799

Intramolecular 1,3-dipolar nitrile oxide cycloaddition using Baylis-Hillman derivatives: stereoselective synthesis of tricyclic chromenoisoxazolines

Bakthadoss, M; Srinivasan, J.; Selvakumar, R.
Synthesis, 2012, 44, 755-766

First Friedel–Crafts reaction of the Baylis–Hillman adducts derived from nitroolefines: Application towards synthesis of pyrrollidines and spiropyrrolidines

Bakthadoss, M.; Sivakumar, N.
Synlett, 2011, 9, 1296-1302

1, 3-Dipoalr cycloaddition on Baylis-Hillman adducts: Novel synthesis of pyrrolidines, spiropyrrolidines and spiropyrrolizidines

Bakthadoss, M.; Sivakumar, N.; Devaraj, A.; Sharada, D. S.
Synthesis, 2011, 13, 2136-2146

First synthesis of bromo and chloro derivatives of Baylis-Hillman adducts derived from nitroolefines: application towards the synthesis of a dendrimercore

Bakthadoss, M.; Sivakumar, N.; Devaraj, A.
Synthesis, 2011, 4, 0611-0618

Highly stereoselective synthesis of tricyclic chromenoisoxazolidines by intramolecular 1, 3-dipolar cycloaddition

Bakthadoss, M.; Murugan, G.,
Eur. J. Org. Chem. 2010, 5825-5830

Solid State Melt Reaction for the domino process: Highly efficient synthesis of fused tetracyclic chromenopyran pyrimidinediones using Baylis-Hillman derivatives
Bakthadoss, M.; Sivakumar, G.; Kannan, D.
Org lett. 2009, 11, 4466-4469

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Novel regio- and stereoselective synthesis of functionalized 3-spiropyrrolidines and 3-spiropyrrolizidines using nitroolefins

Bakthadoss, M.; Sivakumar, N.
Synlett 2009, 6, 1014-1018

Novel synthesis of (E)-3-arylidene-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-ones using Baylis–Hillman derivatives via reductive cyclization

Bakthadoss, M.; Murugan, G.
Synth. Commun. 2009, 39, 1290-1298

A simple and new protocol for the synthesis of novel (Z)-3-arylidenebenzothiazepin-4-ones using Baylis-Hillman derivatives

Bakthadoss, M.; Murugan, G.
Synth. Commun. 2008, 38, 3406-3413

Highly regio- and stereoselective synthesis of tricyclic frameworks using Baylis Hillman derivatives

Bakthadoss, M.; Sivakumar, N.; Sivakumar, G.; Murugan, G.
Tetrahedron Lett. 2008, 49, 820-823

Tandem construction of carbon-carbon and carbon-oxygen bonds in the Baylis-Hillman chemistry: Synthesis of functionalized dl bis allylether

Basavaiah, D.; Bakthadoss, M.; Jayapal Reddy, G.
Synth. Commun. 2002, 32, 689-697

Commemorative Issue in Honor of Prof. B. S. Thyagarajan on the occasion of his retirement from the University of Texas at San Antonio

Negrete, G.R.; Bakthadoss, M.

ARKIVOC: 2001, XI, 1-11

The first intramolecular Fridel-Crafts reaction of the Baylis-Hillman adducts: Synthesis of functionalized indene and indane derivatives

Basavaiah, D.; Bakthadoss, M.; Jayapal Reddy, G.

Synthesis, 2001, 6, 919-923

A new protocol for the synthesis of (E)-3-benzylidinechroman-4-ones: A simple synthesis of the methyl ether of bonducellin

Basavaiah, D.; Bakthadoss, M.; Pandiaraju, S.

Chem. Commun., 1998, 1639-1640

(1R,2R)-2-Nitroxycyclohexan-1-ol: First example of a cyclohexyl-based chiral auxiliary with nitroxy function as diastereo face discriminating group

Basavaiah, D.; Pandiaraju, S.; Bakthadoss, M.; Muthukumaran, K.
Tetrahedron: Asymmetry, 1996, 7, 997-1000

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